Descriptor Definition
8 Seizure
Recent onset. Exclude metabolic, infectious or drug cause
8 Psychosis
Altered ability to function in normal activity due to severe disturbance in the perception of reality. Include hallucinations, incoherence, marked loose associations, impoverished thought content, marked illogical thinking, bizarre, disorganized, or catatonic behavior. Excluded uremia and drug causes.
8 OrganicBrain Syndrome
Altered mental function with impaired orientation, memory or other intelligent function, with rapid onset fluctuating clinical features. Include clouding of consciousness with reduced capacity to focus, and inability to sustain attention to environment, plus at least two of the following: perceptual disturbance, incoherent speech, insomnia or daytime drowsiness, or increased psychomotor activity. Exclude metabolic, infectious or drug causes.
8 Visual Disturbance
Retinal changes of SLE. Include cytoid bodies, retinal hemorrhages, serious exodate or hemorrhages in the choroids, or optic neuritis. Exclude hypertension, infection, or drug causes.
8 Cranial Nerve Disorder
New onset of sensory or motor neuropathy involving cranial nerves.
8 Lupus Headache
Severe persistant headache: may be migrainous, but must be nonresponsive to narcotic analgesia.
New onset of cerebrovascular accident(s). Exclude arteriosclerosis.
8 Vasculitis
Ulceration, gangrene, tender finger nodules, periungual, infarction, splinter hemorrhages, or biopsy or angiogram proof of vasculitis
4 Arthritis
More than 2 joints with pain and signs of inflammation(i.e. tenderness, swelling, or effusion).
4 Myositis
Proximal muscle aching/weakness, associated with elevated creatine phosphokinase/aldolase or electromyogram changes or a biopsy showing myositis.
4 Urinary Casts
Heme-granular or red blood cell casts.
4 Hematuria
>5 red blood cells/high power field. Exclude stone, infection or other cause.
4 Proteinuria
>0.5gm/24hours. New onset or recent increase of more than 0.5gm/24 hours.
4 Pyuria
>5 white blood cells/high power field. Exclude infection.
2 New Rash
New onset or recurrence of inflammatory type rash
2 Alopecia
New onset or recurrence of abnormal, patchy or diffuse loss of hair.
2 Mucosal Ulcers
New onset or recurrence of oral or nasal ulcerations
2 Pleurisy
Pleuritic chest pain with rub or effusion, or pleural thickening.
2 Pericarditis
Pericardial pain with at least 1 of the following: rub, effusion, or electrocardiogram confirmation.
2 Low complement
Decrease in CH50, C3, or C4 below the lower limit of normal for testing laboratory.
2 Increased DNA binding
>25% binding by Farr assay or above normal range for testing laboratory.
1 Fever
>38℃, Exclude infectious cause
1 Thrombocytepenia
<100,000 platelets/mm3.
1 Leukopenia
<3,000 WBC/mm3. Exclude drug causes.